1oke: Difference between revisions
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[[Image:1oke.gif|left|200px]] | [[Image:1oke.gif|left|200px]] | ||
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'''CRYSTAL STRUCTURE OF THE DENGUE 2 VIRUS ENVELOPE PROTEIN IN COMPLEX WITH N-OCTYL-BETA-D-GLUCOSIDE''' | '''CRYSTAL STRUCTURE OF THE DENGUE 2 VIRUS ENVELOPE PROTEIN IN COMPLEX WITH N-OCTYL-BETA-D-GLUCOSIDE''' | ||
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==About this Structure== | ==About this Structure== | ||
1OKE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. This structure supersedes the now removed PDB entry | 1OKE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1oam 1oam]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OKE OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Harrison, S C.]] | [[Category: Harrison, S C.]] | ||
[[Category: Modis, Y.]] | [[Category: Modis, Y.]] | ||
[[Category: | [[Category: Class 2 fusion protein]] | ||
[[Category: | [[Category: Dengue virus]] | ||
[[Category: | [[Category: Flavivirus]] | ||
[[Category: | [[Category: Fusion peptide]] | ||
[[Category: | [[Category: Low-ph conformational change]] | ||
[[Category: | [[Category: Membrane fusion]] | ||
[[Category: | [[Category: Trimer]] | ||
[[Category: | [[Category: Virus/viral protein]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:57:50 2008'' | |||
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Revision as of 03:57, 3 May 2008
CRYSTAL STRUCTURE OF THE DENGUE 2 VIRUS ENVELOPE PROTEIN IN COMPLEX WITH N-OCTYL-BETA-D-GLUCOSIDE
OverviewOverview
Dengue virus is an emerging global health threat. Its major envelope glycoprotein, E, mediates viral attachment and entry by membrane fusion. A crystal structure of the soluble ectodomain of E from dengue virus type 2 reveals a hydrophobic pocket lined by residues that influence the pH threshold for fusion. The pocket, which accepts a hydrophobic ligand, opens and closes through a conformational shift in a beta-hairpin at the interface between two domains. These features point to a structural pathway for the fusion-activating transition and suggest a strategy for finding small-molecule inhibitors of dengue and other flaviviruses.
About this StructureAbout this Structure
1OKE is a Single protein structure of sequence from Dengue virus 2. This structure supersedes the now removed PDB entry 1oam. Full crystallographic information is available from OCA.
ReferenceReference
A ligand-binding pocket in the dengue virus envelope glycoprotein., Modis Y, Ogata S, Clements D, Harrison SC, Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):6986-91. Epub 2003 May 20. PMID:12759475 Page seeded by OCA on Sat May 3 03:57:50 2008