1oj6: Difference between revisions

Revision as of 03:54, 3 May 2008

HUMAN BRAIN NEUROGLOBIN THREE-DIMENSIONAL STRUCTURE

OverviewOverview

Neuroglobin, mainly expressed in vertebrate brain and retina, is a recently identified member of the globin superfamily. Augmenting O(2) supply, neuroglobin promotes survival of neurons upon hypoxic injury, potentially limiting brain damage. In the absence of exogenous ligands, neuroglobin displays a hexacoordinated heme. O(2) and CO bind to the heme iron, displacing the endogenous HisE7 heme distal ligand. Hexacoordinated human neuroglobin displays a classical globin fold adapted to host the reversible bis-histidyl heme complex and an elongated protein matrix cavity, held to facilitate O(2) diffusion to the heme. The neuroglobin structure suggests that the classical globin fold is endowed with striking adaptability, indicating that hemoglobin and myoglobin are just two examples within a wide and functionally diversified protein homology superfamily.

About this StructureAbout this Structure

1OJ6 is a Single protein structure. Full crystallographic information is available from OCA.

ReferenceReference

Human brain neuroglobin structure reveals a distinct mode of controlling oxygen affinity., Pesce A, Dewilde S, Nardini M, Moens L, Ascenzi P, Hankeln T, Burmester T, Bolognesi M, Structure. 2003 Sep;11(9):1087-95. PMID:12962627 Page seeded by OCA on Sat May 3 03:54:43 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:1oj6.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1oj6 |SIZE=350|CAPTION= <scene name='initialview01'>1oj6</scene>, resolution 1.95&Aring;
+The line below this paragraph, containing "STRUCTURE_1oj6", creates the "Structure Box" on the page.
-|SITE= <scene name='pdbsite=AC1:Hem+Binding+Site+For+Chain+D'>AC1</scene>
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1oj6|  PDB=1oj6  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oj6 OCA], [http://www.ebi.ac.uk/pdbsum/1oj6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1oj6 RCSB]</span>
-}}
 '''HUMAN BRAIN NEUROGLOBIN THREE-DIMENSIONAL STRUCTURE'''
@@ Line 35: / Line 32: @@
 [[Category: Neuroglobin]]
 [[Category: Oxygen transport]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 03:54:43 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr  6 08:02:31 2008''