8f8u: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[8f8u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae_subsp._pneumoniae_1158 Klebsiella pneumoniae subsp. pneumoniae 1158]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8F8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8F8U FirstGlance]. <br> | <table><tr><td colspan='2'>[[8f8u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae_subsp._pneumoniae_1158 Klebsiella pneumoniae subsp. pneumoniae 1158]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8F8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8F8U FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8f8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8f8u OCA], [https://pdbe.org/8f8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8f8u RCSB], [https://www.ebi.ac.uk/pdbsum/8f8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8f8u ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8f8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8f8u OCA], [https://pdbe.org/8f8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8f8u RCSB], [https://www.ebi.ac.uk/pdbsum/8f8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8f8u ProSAT]</span></td></tr> | ||
</table> | </table> | ||
Latest revision as of 14:09, 22 November 2023
Bifunctional ligase/repressor BirA from Klebsiella pneumoniae (Domain Swapped Dimer)Bifunctional ligase/repressor BirA from Klebsiella pneumoniae (Domain Swapped Dimer)
Structural highlights
FunctionA0A0W7ZMT5_KLEPN Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.[HAMAP-Rule:MF_00978] |
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