6k5l: Difference between revisions

<table><tr><td colspan='2'>[[6k5l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_o157 Escherichia coli o157]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K5L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6K5L FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">aceK ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1045010 Escherichia coli O157])</td></tr>

[[https://www.uniprot.org/uniprot/A0A1Z3UWE5_ECOLX A0A1Z3UWE5_ECOLX]] Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.[HAMAP-Rule:MF_00747][SAAS:SAAS00963147]

[[Category: Escherichia coli o157]]

[[Category: Jia, Z]]

[[Category: Lei, Z]]

[[Category: Zhang, X]]

[[Category: Zheng, J]]

[[Category: Phosphatase]]