6a8v: Difference between revisions

<table><tr><td colspan='2'>[[6a8v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A8V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6A8V FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6a8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a8v OCA], [https://pdbe.org/6a8v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6a8v RCSB], [https://www.ebi.ac.uk/pdbsum/6a8v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6a8v ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/PHOQ_ECOLI PHOQ_ECOLI] Member of the two-component regulatory system PhoP/PhoQ involved in adaptation to low Mg(2+) environments and the control of acid resistance genes. In low periplasmic Mg(2+), PhoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), acts as a protein phosphatase that dephosphorylates phospho-PhoP, resulting in the repression of PAG and may lead to expression of some PRG (By similarity). PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing (deletion of dsbA/dsbB, or treatment with dithiothreitol). MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway; the 2 periplasmic Cys residues of MgrB are required for its action on PhoQ, which then acts on PhoP. Mediates magnesium influx to the cytosol by activation of mgtA. Promotes expression of the two-component regulatory system rstA/rstB and transcription of the hemL, mgrB, nagA, slyB, vboR and yrbL genes.<ref>PMID:10464230</ref>  

[[Category: Escherichia coli K-12]]

[[Category: Akiyama Y]]

[[Category: Eguchi Y]]

[[Category: Ishii E]]

[[Category: Kato A]]

[[Category: Mori H]]

[[Category: Shiro Y]]

[[Category: Sugimoto H]]

[[Category: Taniguchi K]]

[[Category: Utsumi R]]

[[Category: Yoshitani K]]