5ykh: Difference between revisions

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==Crystal structure of the engineered nine-repeat PUF domain==
==Crystal structure of the engineered nine-repeat PUF domain==
<StructureSection load='5ykh' size='340' side='right' caption='[[5ykh]], [[Resolution|resolution]] 2.46&Aring;' scene=''>
<StructureSection load='5ykh' size='340' side='right'caption='[[5ykh]], [[Resolution|resolution]] 2.46&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5ykh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YKH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YKH FirstGlance]. <br>
<table><tr><td colspan='2'>[[5ykh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YKH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YKH FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.457&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PUM1, KIAA0099, PUMH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ykh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ykh OCA], [http://pdbe.org/5ykh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ykh RCSB], [http://www.ebi.ac.uk/pdbsum/5ykh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ykh ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ykh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ykh OCA], [https://pdbe.org/5ykh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ykh RCSB], [https://www.ebi.ac.uk/pdbsum/5ykh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ykh ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PUM1_HUMAN PUM1_HUMAN]] Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. May be required to support proliferation and self-renewal of stem cells (By similarity).  
[https://www.uniprot.org/uniprot/PUM1_HUMAN PUM1_HUMAN] Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. May be required to support proliferation and self-renewal of stem cells (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Li, H T]]
[[Category: Large Structures]]
[[Category: Wang, J]]
[[Category: Li HT]]
[[Category: Wang, Z X]]
[[Category: Wang J]]
[[Category: Wu, J W]]
[[Category: Wang ZX]]
[[Category: Zhao, Y Y]]
[[Category: Wu JW]]
[[Category: Engineered protein]]
[[Category: Zhao YY]]
[[Category: Puf repeat]]
[[Category: Rna binding protein]]
[[Category: Rna recognition]]

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