5xwz: Difference between revisions

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<StructureSection load='5xwz' size='340' side='right'caption='[[5xwz]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
<StructureSection load='5xwz' size='340' side='right'caption='[[5xwz]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5xwz]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XWZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5XWZ FirstGlance]. <br>
<table><tr><td colspan='2'>[[5xwz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Cladophialophora_bantiana_CBS_173.52 Cladophialophora bantiana CBS 173.52]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XWZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XWZ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5xwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xwz OCA], [http://pdbe.org/5xwz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xwz RCSB], [http://www.ebi.ac.uk/pdbsum/5xwz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xwz ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xwz OCA], [https://pdbe.org/5xwz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xwz RCSB], [https://www.ebi.ac.uk/pdbsum/5xwz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xwz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A0D2H023_XYLBA A0A0D2H023_XYLBA]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cladophialophora bantiana CBS 173 52]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Chen, C C]]
[[Category: Chen CC]]
[[Category: Guo, R T]]
[[Category: Guo RT]]
[[Category: Liu, W D]]
[[Category: Liu WD]]
[[Category: Liu, W T]]
[[Category: Liu WT]]
[[Category: Zheng, Y Y]]
[[Category: Zheng YY]]
[[Category: Alpha/beta-hydrolase]]
[[Category: Hydrolase]]
[[Category: Lactonase]]
[[Category: Zearalenone]]

Latest revision as of 11:16, 22 November 2023

Crystal structure of a lactonase from Cladophialophora bantianaCrystal structure of a lactonase from Cladophialophora bantiana

Structural highlights

5xwz is a 4 chain structure with sequence from Cladophialophora bantiana CBS 173.52. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.75Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

A0A0D2H023_XYLBA

Publication Abstract from PubMed

Zearalenone (ZEN) is a mycotoxin which causes huge economic losses in the food and animal feed industries. The lactonase ZHD101 from Clonostachys rosea, which catalyzes the hydrolytic degradation of ZEN, is the only known ZEN-detoxifying enzyme. Here, a protein homologous to ZHD101, denoted CbZHD, from Cladophialophora batiana was expressed and characterized. Sequence alignment indicates that CbZHD possesses the same catalytic triad and ZEN-interacting residues as found in ZHD101. CbZHD exhibits optimal enzyme activity at 35 degrees C and pH 8, and is sensitive to heat treatment. The crystal structure of apo CbZHD was determined to 1.75 A resolution. The active-site compositions of CbZHD and ZHD101 were analyzed.

Characterization and crystal structure of a novel zearalenone hydrolase from Cladophialophora bantiana.,Hui R, Hu X, Liu W, Liu W, Zheng Y, Chen Y, Guo RT, Jin J, Chen CC Acta Crystallogr F Struct Biol Commun. 2017 Sep 1;73(Pt 9):515-519. doi:, 10.1107/S2053230X17011840. Epub 2017 Aug 21. PMID:28876230[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

  1. ↑ Hui R, Hu X, Liu W, Liu W, Zheng Y, Chen Y, Guo RT, Jin J, Chen CC. Characterization and crystal structure of a novel zearalenone hydrolase from Cladophialophora bantiana. Acta Crystallogr F Struct Biol Commun. 2017 Sep 1;73(Pt 9):515-519. doi:, 10.1107/S2053230X17011840. Epub 2017 Aug 21. PMID:28876230 doi:http://dx.doi.org/10.1107/S2053230X17011840

5xwz, resolution 1.75Å

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