1ocr: Difference between revisions

Revision as of 03:40, 3 May 2008

BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE

OverviewOverview

Crystal structures of bovine heart cytochrome c oxidase in the fully oxidized, fully reduced, azide-bound, and carbon monoxide-bound states were determined at 2.30, 2.35, 2.9, and 2.8 angstrom resolution, respectively. An aspartate residue apart from the O2 reduction site exchanges its effective accessibility to the matrix aqueous phase for one to the cytosolic phase concomitantly with a significant decrease in the pK of its carboxyl group, on reduction of the metal sites. The movement indicates the aspartate as the proton pumping site. A tyrosine acidified by a covalently linked imidazole nitrogen is a possible proton donor for the O2 reduction by the enzyme.

About this StructureAbout this Structure

1OCR is a Protein complex structure of sequences from Bos taurus. Full crystallographic information is available from OCA.

ReferenceReference

Redox-coupled crystal structural changes in bovine heart cytochrome c oxidase., Yoshikawa S, Shinzawa-Itoh K, Nakashima R, Yaono R, Yamashita E, Inoue N, Yao M, Fei MJ, Libeu CP, Mizushima T, Yamaguchi H, Tomizaki T, Tsukihara T, Science. 1998 Jun 12;280(5370):1723-9. PMID:9624044 Page seeded by OCA on Sat May 3 03:40:25 2008

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OCA

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- {{Structure
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-}}
 '''BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE'''
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 [[Category: Tsukihara, T.]]
 [[Category: Yao, M.]]
-[[Category: cytochrome c oxidase]]
+[[Category: Cytochrome c oxidase]]
-[[Category: oxidoreductase (cytochrome(c)-oxygen)]]
+[[Category: Reduced]]
-[[Category: reduced]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 03:40:25 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:43:18 2008''