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| | '''Unreleased structure''' |
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| ==The Crystal Structure of CASP1 from Biortus==
| | The entry 8wra is ON HOLD |
| <StructureSection load='8wra' size='340' side='right'caption='[[8wra]], [[Resolution|resolution]] 1.45Å' scene=''>
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| == Structural highlights ==
| | Authors: |
| <table><tr><td colspan='2'>[[8wra]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WRA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WRA FirstGlance]. <br>
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| </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45Å</td></tr>
| | Description: |
| <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
| | [[Category: Unreleased Structures]] |
| <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wra FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wra OCA], [https://pdbe.org/8wra PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wra RCSB], [https://www.ebi.ac.uk/pdbsum/8wra PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wra ProSAT]</span></td></tr>
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| </table>
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| == Function ==
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| [https://www.uniprot.org/uniprot/CASP1_HUMAN CASP1_HUMAN] Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.<ref>PMID:7876192</ref> <ref>PMID:15498465</ref>
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| == References ==
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| <references/>
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| __TOC__
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| </StructureSection>
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| [[Category: Homo sapiens]]
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| [[Category: Large Structures]] | |
| [[Category: Cheng W]]
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| [[Category: Guo S]]
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| [[Category: Lin D]]
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| [[Category: Wang F]]
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| [[Category: Yuan Z]]
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