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| | '''Unreleased structure''' |
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| ==Gaussian mixture model based single particle refinement - ABC transporter (inhibitor-bound ABCG2 from EMPIAR-10374)==
| | The entry 8u2c is ON HOLD until Paper Publication |
| <StructureSection load='8u2c' size='340' side='right'caption='[[8u2c]], [[Resolution|resolution]] 2.50Å' scene=''>
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| == Structural highlights ==
| | Authors: Chen, M., Pintilie, G. |
| <table><tr><td colspan='2'>[[8u2c]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8U2C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8U2C FirstGlance]. <br>
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| </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.5Å</td></tr>
| | Description: Gaussian mixture model based single particle refinement -ABC transporter (inhibitor-bound ABCG2 from EMPIAR-10374) |
| <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8u2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8u2c OCA], [https://pdbe.org/8u2c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8u2c RCSB], [https://www.ebi.ac.uk/pdbsum/8u2c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8u2c ProSAT]</span></td></tr>
| | [[Category: Unreleased Structures]] |
| </table>
| | [[Category: Chen, M]] |
| == Function ==
| | [[Category: Pintilie, G]] |
| [https://www.uniprot.org/uniprot/ABCG2_HUMAN ABCG2_HUMAN] High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.<ref>PMID:12958161</ref> <ref>PMID:20705604</ref> <ref>PMID:22132962</ref> <ref>PMID:23189181</ref>
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| == References ==
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| <references/>
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| __TOC__
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| </StructureSection>
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| [[Category: Homo sapiens]]
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| [[Category: Large Structures]] | |
| [[Category: Mus musculus]]
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| [[Category: Chen M]] | |
| [[Category: Pintilie G]] | |
Unreleased structure
The entry 8u2c is ON HOLD until Paper Publication
Authors: Chen, M., Pintilie, G.
Description: Gaussian mixture model based single particle refinement -ABC transporter (inhibitor-bound ABCG2 from EMPIAR-10374)