1ob7: Difference between revisions

Revision as of 03:37, 3 May 2008

CEPHAIBOL C

OverviewOverview

The crystal structures of the peptaibol antibiotics cephaibol A, cephaibol B and cephaibol C have been determined at ca. 0.9 A resolution. All three adopt a helical conformation with a sharp bend (of about 55 degrees) at the central hydroxyproline. All isovalines were found to possess the D configuration, superposition of all four models (there are two independent molecules in the cephaibol B structure) shows that the N-terminal helix is rigid and the C-terminus is flexible. There are differences in the hydrogen bonding patterns for the three structures that crystallize in different space groups despite relatively similar unit cell dimensions, but only in the case of cephaibol C does the packing emulate the formation of a membrane channel believed to be important for their biological function.

About this StructureAbout this Structure

1OB7 is a Single protein structure of sequence from Acremonium tubakii. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structures of cephaibols., Bunkoczi G, Schiell M, Vertesy L, Sheldrick GM, J Pept Sci. 2003 Nov-Dec;9(11-12):745-52. PMID:14658793 Page seeded by OCA on Sat May 3 03:37:20 2008

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OCA

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 [[Image:1ob7.jpg|left|200px]]
- {{Structure
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-}}
 '''CEPHAIBOL C'''
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 [[Category: Sheldrick, G M.]]
 [[Category: Vertesy, L.]]
-[[Category: antibiotic]]
+[[Category: Antibiotic]]
-[[Category: cephaibol]]
+[[Category: Cephaibol]]
-[[Category: ion channel]]
+[[Category: Ion channel]]
-[[Category: peptaibol]]
+[[Category: Peptaibol]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 03:37:20 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:42:44 2008''