8gq4: Difference between revisions

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'''Unreleased structure'''


The entry 8gq4 is ON HOLD
==Histone acetyltransferase Rtt109 mutant-N195A==
 
<StructureSection load='8gq4' size='340' side='right'caption='[[8gq4]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
Authors: Chen, Y.J., Su, D.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8gq4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GQ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GQ4 FirstGlance]. <br>
Description: Histone acetyltransferase Rtt109 mutant-N195A
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.77&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
[[Category: Chen, Y.J]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gq4 OCA], [https://pdbe.org/8gq4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gq4 RCSB], [https://www.ebi.ac.uk/pdbsum/8gq4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gq4 ProSAT]</span></td></tr>
[[Category: Su, D]]
</table>
== Function ==
[https://www.uniprot.org/uniprot/RT109_CANAL RT109_CANAL] Histone chaperone-dependent acetylase that modifies 'Lys-56' of histone H3 (H3K56ac), to promote genomic stability, DNA repair and transcriptional regulation during mitotic S-phase (PubMed:20601951, PubMed:20080646). Plays an important role in the regulation of white-opaque genotoxin induced-switching (PubMed:21749487).<ref>PMID:20080646</ref> <ref>PMID:20601951</ref> <ref>PMID:21749487</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Candida albicans]]
[[Category: Large Structures]]
[[Category: Chen YJ]]
[[Category: Su D]]

Revision as of 14:37, 15 November 2023

Histone acetyltransferase Rtt109 mutant-N195AHistone acetyltransferase Rtt109 mutant-N195A

Structural highlights

8gq4 is a 1 chain structure with sequence from Candida albicans. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.77Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RT109_CANAL Histone chaperone-dependent acetylase that modifies 'Lys-56' of histone H3 (H3K56ac), to promote genomic stability, DNA repair and transcriptional regulation during mitotic S-phase (PubMed:20601951, PubMed:20080646). Plays an important role in the regulation of white-opaque genotoxin induced-switching (PubMed:21749487).[1] [2] [3]

References

  1. ↑ Lopes da Rosa J, Boyartchuk VL, Zhu LJ, Kaufman PD. Histone acetyltransferase Rtt109 is required for Candida albicans pathogenesis. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1594-9. PMID:20080646 doi:10.1073/pnas.0912427107
  2. ↑ Wurtele H, Tsao S, Lépine G, Mullick A, Tremblay J, Drogaris P, Lee EH, Thibault P, Verreault A, Raymond M. Modulation of histone H3 lysine 56 acetylation as an antifungal therapeutic strategy. Nat Med. 2010 Jul;16(7):774-80. PMID:20601951 doi:10.1038/nm.2175
  3. ↑ Stevenson JS, Liu H. Regulation of white and opaque cell-type formation in Candida albicans by Rtt109 and Hst3. Mol Microbiol. 2011 Aug;81(4):1078-91. PMID:21749487 doi:10.1111/j.1365-2958.2011.07754.x

8gq4, resolution 1.77Å

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