2vd6: Difference between revisions

<table><tr><td colspan='2'>[[2vd6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VD6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VD6 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2SA:2-[9-(3,4-DIHYDROXY-5-PHOSPHONOOXYMETHYL-TETRAHYDRO-FURAN-2-YL)-9H-PURIN-6-YLAMINO]-SUCCINIC+ACID'>2SA</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FUM:FUMARIC+ACID'>FUM</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>

<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Adenylosuccinate_lyase Adenylosuccinate lyase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.2.2 4.3.2.2] </span></td></tr>

[[https://www.uniprot.org/uniprot/PUR8_HUMAN PUR8_HUMAN]] Defects in ADSL are the cause of adenylosuccinase deficiency (ADSL deficiency) [MIM:[https://omim.org/entry/103050 103050]]. ADSL deficiency is an autosomal recessive disorder characterized by the accumulation in the body fluids of succinylaminoimidazole-carboxamide riboside (SAICA-riboside) and succinyladenosine (S-Ado). Most children display marked psychomotor delay, often accompanied by epilepsy or autistic features, or both, although some patients may be less profoundly retarded. Occasionally, growth retardation and muscular wasting are also present.  

[[Category: Adenylosuccinate lyase]]

[[Category: Human]]

[[Category: Arrowsmith, C]]

[[Category: Berg, S van den]]

[[Category: Berglund, H]]

[[Category: Busam, R]]

[[Category: Collins, R]]

[[Category: Dahlgren, L G]]

[[Category: Edwards, A]]

[[Category: Flodin, S]]

[[Category: Flores, A]]

[[Category: Graslund, S]]

[[Category: Hallberg, B M]]

[[Category: Hammarstrom, M]]

[[Category: Holmberg-schiavone, L]]

[[Category: Johansson, I]]

[[Category: Kallas, A]]

[[Category: Karlberg, T]]

[[Category: Kotenyova, T]]

[[Category: Lehtio, L]]

[[Category: Moche, M]]

[[Category: Nilsson, M]]

[[Category: Nordlund, P]]

[[Category: Nyman, T]]

[[Category: Ogg, D]]

[[Category: Persson, C]]

[[Category: Structural genomic]]

[[Category: Sagemark, J]]

[[Category: Stenmark, P]]

[[Category: Sundstrom, M]]

[[Category: Thorsell, A G]]

[[Category: Tresaugues, L]]

[[Category: Weigelt, J]]

[[Category: Welin, M]]

[[Category: Epilepsy]]

[[Category: Purine metabolism]]