Sequestosome

Function Sequestosome (SQS) or p62, is required for the formation and autophagic degredation of polyubiquitin-containg bodies. SQS may regulate signaling cascades through ubiquitination. Structural highlights SQS is a multi-domain protein. SQS domain structure includes: PB1 domain which contains Phox and Berm1 ZZ-type zinc finger SMIR – SOD interaction domain TB – TRAF6 binding motif LC3 – microtubule-associated protein 1 light chain 3B LIR – interaction region UBA – ubiquitin association domain. Relevance SQS is associated with fibrillary tangles in Alzheimer disease. 3D structures of sequestosome Updated on 10-May-2025 Domains: PB1 1-102; ZZ 120-180; UBA 387-436 1q02, 2jy7, 2jy8, 2k0b, 2knv – hSQS UBA domain – human - NMR 6jm4 – hSQS-1 PB1 domain (mutant) 4uf8, 4uf9, 6tgy, 6th3 – hSQS-1 PB1 domain – Cryo EM 5yp7, 5yp8, 5ypa, 5ypb, 5ypc, 5ype, 5ypg, 5yph, 5ypi, 6miu – hSQS-1 ZZ domain 6mj7 – hSQS-1 ZZ domain + Arg 6khz – hSQS-1 ZZ domain + Gly 7r1o – hSQS-1 ZZ domain + drug 2ktr – rSQS PB1 domain – rat - NMR 2kkc – rSQS PB1 domain (mutant) - NMR 4mjs – hSQS-1 PB1 domain + protein kinase C zeta type 3b0f – mSQS UBA domain – mouse 2rru – mSQS UBA domain - NMR

spinqualitylabelsall models Structure of human sequestosome UBA domain (PDB code 2jy8) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image