2h77: Difference between revisions
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<StructureSection load='2h77' size='340' side='right'caption='[[2h77]], [[Resolution|resolution]] 2.33Å' scene=''> | <StructureSection load='2h77' size='340' side='right'caption='[[2h77]], [[Resolution|resolution]] 2.33Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2h77]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2h77]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H77 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H77 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.33Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene>, <scene name='pdbligand=T3:3,5,3TRIIODOTHYRONINE'>T3</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h77 OCA], [https://pdbe.org/2h77 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h77 RCSB], [https://www.ebi.ac.uk/pdbsum/2h77 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h77 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h77 OCA], [https://pdbe.org/2h77 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h77 RCSB], [https://www.ebi.ac.uk/pdbsum/2h77 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h77 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | |||
[https://www.uniprot.org/uniprot/THA_HUMAN THA_HUMAN] Defects in THRA are the cause of congenital hypothyroidism non-goitrous type 6 (CHNG6) [MIM:[https://omim.org/entry/614450 614450]. A disease characterized by growth retardation, developmental retardation, skeletal dysplasia, borderline low thyroxine levels and high triiodothyronine levels. There is differential sensitivity to thyroid hormone action, with retention of hormone responsiveness in the hypothalamic pituitary axis and liver but skeletal, gastrointestinal, and myocardial resistance.<ref>PMID:22168587</ref> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/THA_HUMAN THA_HUMAN] Nuclear hormone receptor. High affinity receptor for triiodothyronine. | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Ambrosio | [[Category: Ambrosio ALB]] | ||
[[Category: Aparicio | [[Category: Aparicio R]] | ||
[[Category: Baxter | [[Category: Baxter JD]] | ||
[[Category: Bleicher | [[Category: Bleicher L]] | ||
[[Category: Craievich | [[Category: Craievich AF]] | ||
[[Category: Dias | [[Category: Dias SMG]] | ||
[[Category: Figueira | [[Category: Figueira ACM]] | ||
[[Category: Fischer | [[Category: Fischer H]] | ||
[[Category: Garrat | [[Category: Garrat RC]] | ||
[[Category: Nascimento | [[Category: Nascimento AS]] | ||
[[Category: Neto | [[Category: Neto MO]] | ||
[[Category: Nunes | [[Category: Nunes FM]] | ||
[[Category: Polikarpov | [[Category: Polikarpov I]] | ||
[[Category: Santos | [[Category: Santos MAM]] | ||
[[Category: Togashi | [[Category: Togashi HFM]] | ||
[[Category: Webb | [[Category: Webb P]] | ||