7zrt: Difference between revisions

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-'''Unreleased structure'''
-The entry 7zrt is ON HOLD  until Paper Publication
+==Crystal structure of human Urokinase-type plasminogen activator in complex with bicycle peptide inhibitor UK970==
+<StructureSection load='7zrt' size='340' side='right'caption='[[7zrt]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-Authors: Caregnato, A., Angela, P., Mazzoccato, Y., Frasson, N., Angelini, A., Cendron, L.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7zrt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZRT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZRT FirstGlance]. <br>
-Description: Crystal structure of human Urokinase-type plasminogen activator in complex with bicycle peptide inhibitor UK970
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZBR:1,3,5-TRIS(BROMOMETHYL)BENZENE'>ZBR</scene></td></tr>
-[[Category: Angelini, A]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zrt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zrt OCA], [https://pdbe.org/7zrt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zrt RCSB], [https://www.ebi.ac.uk/pdbsum/7zrt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zrt ProSAT]</span></td></tr>
-[[Category: Caregnato, A]]
+</table>
-[[Category: Cendron, L]]
+== Disease ==
-[[Category: Angela, P]]
+[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[https://omim.org/entry/601709 601709]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>
-[[Category: Frasson, N]]
+== Function ==
-[[Category: Mazzoccato, Y]]
+[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Synthetic construct]]
+[[Category: Angela P]]
+[[Category: Angelini A]]
+[[Category: Caregnato A]]
+[[Category: Cendron L]]
+[[Category: Frasson N]]
+[[Category: Mazzoccato Y]]