1o80: Difference between revisions
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'''CRYSTAL STRUCTURE OF IP-10 H-FORM''' | '''CRYSTAL STRUCTURE OF IP-10 H-FORM''' | ||
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==About this Structure== | ==About this Structure== | ||
1O80 is a [[Single protein]] structure | 1O80 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O80 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Papageorgiou, A C.]] | [[Category: Papageorgiou, A C.]] | ||
[[Category: Swaminathan, G J.]] | [[Category: Swaminathan, G J.]] | ||
[[Category: | [[Category: Chemokine,interferon induction,chemotaxis,inflammatory response]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:30:10 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 03:30, 3 May 2008
CRYSTAL STRUCTURE OF IP-10 H-FORM
OverviewOverview
We have determined the structure of wild-type IP-10 from three crystal forms. The crystals provide eight separate models of the IP-10 chain, all differing substantially from a monomeric IP-10 variant examined previously by NMR spectroscopy. In each crystal form, IP-10 chains form conventional beta sheet dimers, which, in turn, form a distinct tetrameric assembly. The M form tetramer is reminiscent of platelet factor 4, whereas the T and H forms feature a novel twelve-stranded beta sheet. Analytical ultracentrifugation indicates that, in free solution, IP-10 exists in a monomer-dimer equilibrium with a dissociation constant of 9 microM. We propose that the tetrameric structures may represent species promoted by the binding of glycosaminoglycans. The binding sites for several IP-10-neutralizing mAbs have also been mapped.
About this StructureAbout this Structure
1O80 is a Single protein structure. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structures of oligomeric forms of the IP-10/CXCL10 chemokine., Swaminathan GJ, Holloway DE, Colvin RA, Campanella GK, Papageorgiou AC, Luster AD, Acharya KR, Structure. 2003 May;11(5):521-32. PMID:12737818 Page seeded by OCA on Sat May 3 03:30:10 2008