4ysh: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4ysh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_kaustophilus_HTA426 Geobacillus kaustophilus HTA426]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YSH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YSH FirstGlance]. <br> | <table><tr><td colspan='2'>[[4ysh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_kaustophilus_HTA426 Geobacillus kaustophilus HTA426]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YSH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YSH FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ysh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ysh OCA], [https://pdbe.org/4ysh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ysh RCSB], [https://www.ebi.ac.uk/pdbsum/4ysh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ysh ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ysh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ysh OCA], [https://pdbe.org/4ysh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ysh RCSB], [https://www.ebi.ac.uk/pdbsum/4ysh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ysh ProSAT]</span></td></tr> | ||
</table> | </table> | ||
Latest revision as of 18:38, 8 November 2023
Crystal structure of glycine oxidase from Geobacillus kaustophilusCrystal structure of glycine oxidase from Geobacillus kaustophilus
Structural highlights
FunctionGLYOX_GEOKA Catalyzes the FAD-dependent oxidative deamination of various amines and D-amino acids to yield the corresponding alpha-keto acids, ammonia/amine, and hydrogen peroxide. Oxidizes glycine, sarcosine (N-methylglycine), N-ethylglycine, D-proline, D-alanine, glycine-ethyl ester, and some other D-amino acids. Does not act on L-proline (PubMed:17894345). Is essential for thiamine biosynthesis since the oxidation of glycine catalyzed by ThiO generates the glycine imine intermediate (dehydroglycine) required for the biosynthesis of the thiazole ring of thiamine pyrophosphate (By similarity).[UniProtKB:O31616][1] References
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