4ls1: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4ls1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LS1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LS1 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4ls1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LS1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LS1 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3X2:2-[(E)-{2-[4-(2-CHLOROPHENYL)-1,3-THIAZOL-2-YL]HYDRAZINYLIDENE}METHYL]BENZOIC+ACID'>3X2</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3X2:2-[(E)-{2-[4-(2-CHLOROPHENYL)-1,3-THIAZOL-2-YL]HYDRAZINYLIDENE}METHYL]BENZOIC+ACID'>3X2</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ls1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ls1 OCA], [https://pdbe.org/4ls1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ls1 RCSB], [https://www.ebi.ac.uk/pdbsum/4ls1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ls1 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ls1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ls1 OCA], [https://pdbe.org/4ls1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ls1 RCSB], [https://www.ebi.ac.uk/pdbsum/4ls1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ls1 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
Latest revision as of 17:37, 8 November 2023
Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A312Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A312
Structural highlights
DiseasePYRD_HUMAN Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:263750; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.[1] FunctionPYRD_HUMAN Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. See AlsoReferences
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