4hy6: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| Line 4: | Line 4: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4hy6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HY6 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4hy6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HY6 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FJ1:6,6-DIMETHYL-3-(TRIFLUOROMETHYL)-1,5,6,7-TETRAHYDRO-4H-INDAZOL-4-ONE'>FJ1</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.649Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FJ1:6,6-DIMETHYL-3-(TRIFLUOROMETHYL)-1,5,6,7-TETRAHYDRO-4H-INDAZOL-4-ONE'>FJ1</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hy6 OCA], [https://pdbe.org/4hy6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hy6 RCSB], [https://www.ebi.ac.uk/pdbsum/4hy6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hy6 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hy6 OCA], [https://pdbe.org/4hy6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hy6 RCSB], [https://www.ebi.ac.uk/pdbsum/4hy6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hy6 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
Latest revision as of 17:11, 8 November 2023
Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ1Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ1
Structural highlights
FunctionHS90A_HUMAN Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.[1] [2] See AlsoReferences
|
| ||||||||||||||||||