3wnq: Difference between revisions
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<StructureSection load='3wnq' size='340' side='right'caption='[[3wnq]], [[Resolution|resolution]] 2.95Å' scene=''> | <StructureSection load='3wnq' size='340' side='right'caption='[[3wnq]], [[Resolution|resolution]] 2.95Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3wnq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3wnq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_parapsilosis Candida parapsilosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WNQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WNQ FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.95Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HXT:2-HYDROXY-1-PHENYLETHANONE'>HXT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wnq OCA], [https://pdbe.org/3wnq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wnq RCSB], [https://www.ebi.ac.uk/pdbsum/3wnq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wnq ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wnq OCA], [https://pdbe.org/3wnq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wnq RCSB], [https://www.ebi.ac.uk/pdbsum/3wnq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wnq ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/A1X808_CANPA A1X808_CANPA] | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Candida parapsilosis]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Chan | [[Category: Chan HC]] | ||
[[Category: Guo | [[Category: Guo RT]] | ||
[[Category: Huang | [[Category: Huang CH]] | ||
[[Category: Ko | [[Category: Ko TP]] | ||
[[Category: Nie | [[Category: Nie Y]] | ||
[[Category: Wang | [[Category: Wang SS]] | ||
[[Category: Xiao | [[Category: Xiao R]] | ||
[[Category: Xu | [[Category: Xu Y]] | ||
[[Category: Zhang | [[Category: Zhang RZ]] | ||
Latest revision as of 16:17, 8 November 2023
Crystal structure of (R)-carbonyl reductase H49A mutant from Candida Parapsilosis in complex with 2-hydroxyacetophenoneCrystal structure of (R)-carbonyl reductase H49A mutant from Candida Parapsilosis in complex with 2-hydroxyacetophenone
Structural highlights
FunctionPublication Abstract from PubMedStructure-guided design of substrate-binding pocket inversed the stereoselectivity of an NADH-dependent medium-chain alcohol dehydrogenase (MDR) from Prelog to anti-Prelog. The pocket-forming amino acids, especially the unconserved residues as hotspots, play critical roles in directing MDRs' stereoselectivity. Unconserved substrate-binding sites direct the stereoselectivity of medium-chain alcohol dehydrogenase.,Wang S, Nie Y, Xu Y, Zhang R, Ko TP, Huang CH, Chan HC, Guo RT, Xiao R Chem Commun (Camb). 2014 Jun 24;50(58):7770-2. doi: 10.1039/c4cc01752h. PMID:24834985[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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