3uzc: Difference between revisions
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<StructureSection load='3uzc' size='340' side='right'caption='[[3uzc]], [[Resolution|resolution]] 3.34Å' scene=''> | <StructureSection load='3uzc' size='340' side='right'caption='[[3uzc]], [[Resolution|resolution]] 3.34Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3uzc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3uzc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UZC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UZC FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.341Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=T4E:4-(3-AMINO-5-PHENYL-1,2,4-TRIAZIN-6-YL)-2-CHLOROPHENOL'>T4E</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uzc OCA], [https://pdbe.org/3uzc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uzc RCSB], [https://www.ebi.ac.uk/pdbsum/3uzc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uzc ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uzc OCA], [https://pdbe.org/3uzc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uzc RCSB], [https://www.ebi.ac.uk/pdbsum/3uzc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uzc ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/AA2AR_HUMAN AA2AR_HUMAN] Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Andrews | [[Category: Andrews SP]] | ||
[[Category: Congreve | [[Category: Congreve M]] | ||
[[Category: Dore | [[Category: Dore AS]] | ||
[[Category: Hollenstein | [[Category: Hollenstein K]] | ||
[[Category: Hurrell | [[Category: Hurrell E]] | ||
[[Category: Langmead | [[Category: Langmead CJ]] | ||
[[Category: Marshall | [[Category: Marshall FH]] | ||
[[Category: Mason | [[Category: Mason JS]] | ||
[[Category: Ng | [[Category: Ng IW]] | ||
[[Category: Weir | [[Category: Weir M]] | ||
[[Category: Zhukov | [[Category: Zhukov A]] | ||
Latest revision as of 15:15, 8 November 2023
Thermostabilised Adenosine A2A receptor in complex with 4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenolThermostabilised Adenosine A2A receptor in complex with 4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
Structural highlights
FunctionAA2AR_HUMAN Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Publication Abstract from PubMedPotent, ligand efficient, selective, and orally efficacious 1,2,4-triazine derivatives have been identified using structure based drug design approaches as antagonists of the adenosine A(2A) receptor. The X-ray crystal structures of compounds 4e and 4g bound to the GPCR illustrate that the molecules bind deeply inside the orthosteric binding cavity. In vivo pharmacokinetic and efficacy data for compound 4k are presented, demonstrating the potential of this series of compounds for the treatment of Parkinson's disease. Discovery of 1,2,4-Triazine Derivatives as Adenosine A(2A) Antagonists using Structure Based Drug Design.,Congreve M, Andrews SP, Dore AS, Hollenstein K, Hurrell E, Langmead CJ, Mason JS, Ng IW, Tehan B, Zhukov A, Weir M, Marshall FH J Med Chem. 2012 Mar 8;55(5):1898-903. Epub 2012 Jan 27. PMID:22220592[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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