3ub3: Difference between revisions
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<StructureSection load='3ub3' size='340' side='right'caption='[[3ub3]], [[Resolution|resolution]] 2.75Å' scene=''> | <StructureSection load='3ub3' size='340' side='right'caption='[[3ub3]], [[Resolution|resolution]] 2.75Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3ub3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3ub3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UB3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UB3 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ub3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ub3 OCA], [https://pdbe.org/3ub3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ub3 RCSB], [https://www.ebi.ac.uk/pdbsum/3ub3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ub3 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ub3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ub3 OCA], [https://pdbe.org/3ub3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ub3 RCSB], [https://www.ebi.ac.uk/pdbsum/3ub3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ub3 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/TIRAP_HUMAN TIRAP_HUMAN] Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.<ref>PMID:18292575</ref> <ref>PMID:19509286</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Lin | [[Category: Lin Z]] | ||
[[Category: Shen | [[Category: Shen Y]] | ||