3ipv: Difference between revisions
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<StructureSection load='3ipv' size='340' side='right'caption='[[3ipv]], [[Resolution|resolution]] 2.04Å' scene=''> | <StructureSection load='3ipv' size='340' side='right'caption='[[3ipv]], [[Resolution|resolution]] 2.04Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3ipv]] is a 4 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3ipv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Spatholobus_parviflorus Spatholobus parviflorus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IPV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IPV FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.04Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ipv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ipv OCA], [https://pdbe.org/3ipv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ipv RCSB], [https://www.ebi.ac.uk/pdbsum/3ipv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ipv ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/LECA_SPAPA LECA_SPAPA] | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Spatholobus parviflorus]] | [[Category: Spatholobus parviflorus]] | ||
[[Category: Abhilash | [[Category: Abhilash J]] | ||
[[Category: Bharath | [[Category: Bharath SR]] | ||
[[Category: Geethanandan | [[Category: Geethanandan K]] | ||
[[Category: Haridas | [[Category: Haridas M]] | ||
[[Category: Sadasivan | [[Category: Sadasivan C]] | ||
Latest revision as of 19:01, 1 November 2023
Crystal structure of Spatholobus parviflorus seed lectinCrystal structure of Spatholobus parviflorus seed lectin
Structural highlights
FunctionEvolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedA galactose-specific seed lectin from Spatholobous parviflorus (SPL) has been purified, crystallized and its X-ray structure solved. It is the first lectin purified and crystallized from the genus Spatholobus (family: Fabaceae). The crystals belong to the space group P1, with a=60.792 A, b=60.998 A, c=78.179 A, alpha=78.68 degrees , beta=88.62 degrees , gamma=104.32 degrees . The data were collected at 2.04 A resolution under cryocondition, on a MAR image-plate detector system, mounted on a rotating anode X-ray generator. The coordinates of Dolichos biflorus lectin (1lu1) were successfully used for the structure solution by molecular replacement method. The primary structure of the SPL was not known earlier and it was unambiguously visible in the electron density. S. parviflorus lectin is a hetero-dimeric-tetramer with two alpha and two beta chains of 251 and 239 residues respectively. SPL has two metal ions, Ca(2+) and Mn(2+), bound to a loop region of each chain. The SPL monomers are in jelly roll form. X-ray structure of a galactose-specific lectin from Spatholobous parviflorous.,Geethanandan K, Abhilash J, Bharath SR, Sadasivan C, Haridas M Int J Biol Macromol. 2011 Dec 1;49(5):992-8. Epub 2011 Aug 26. PMID:21889532[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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