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3f2o: Difference between revisions

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<StructureSection load='3f2o' size='340' side='right'caption='[[3f2o]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
<StructureSection load='3f2o' size='340' side='right'caption='[[3f2o]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3f2o]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F2O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F2O FirstGlance]. <br>
<table><tr><td colspan='2'>[[3f2o]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F2O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F2O FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SPSB1, SSB1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f2o OCA], [https://pdbe.org/3f2o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f2o RCSB], [https://www.ebi.ac.uk/pdbsum/3f2o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f2o ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f2o OCA], [https://pdbe.org/3f2o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f2o RCSB], [https://www.ebi.ac.uk/pdbsum/3f2o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f2o ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/SPSB1_HUMAN SPSB1_HUMAN]] Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.<ref>PMID:15601820</ref> [[https://www.uniprot.org/uniprot/VASA1_DROME VASA1_DROME]] Involved in translational control mechanisms operating in early stages of oogenesis. Required maternally in many stages of oogenesis, including cystocyte differentiation, oocyte differentiation, and specification of anterior-posterior polarity in the developing cysts. Essential for the formation and/or structural integrity of perinuclear nuage particles during germ cell formation. Required for gus, Fsn and aub accumulation at the posterior pole of the embryo. Required for the localization of vas to the perinuclear region of nurse cells.<ref>PMID:10678180</ref> <ref>PMID:11526087</ref> <ref>PMID:12479811</ref> <ref>PMID:14588248</ref> <ref>PMID:16630817</ref> <ref>PMID:18590813</ref> <ref>PMID:20123973</ref> <ref>PMID:3052853</ref> <ref>PMID:3140040</ref> <ref>PMID:8026330</ref> <ref>PMID:9521895</ref> 
[https://www.uniprot.org/uniprot/SPSB1_HUMAN SPSB1_HUMAN] Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.<ref>PMID:15601820</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Drosophila melanogaster]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith CH]]
[[Category: Bountra, C]]
[[Category: Bountra C]]
[[Category: Bullock, A]]
[[Category: Bullock A]]
[[Category: Delft, F Von]]
[[Category: Edwards AM]]
[[Category: Edwards, A M]]
[[Category: Filippakopoulos P]]
[[Category: Filippakopoulos, P]]
[[Category: Keates T]]
[[Category: Keates, T]]
[[Category: Knapp S]]
[[Category: Knapp, S]]
[[Category: Murray JW]]
[[Category: Murray, J W]]
[[Category: Pike ACW]]
[[Category: Pike, A C.W]]
[[Category: Roos A]]
[[Category: Roos, A]]
[[Category: Savitsky P]]
[[Category: Structural genomic]]
[[Category: Sharpe T]]
[[Category: Savitsky, P]]
[[Category: Von Delft F]]
[[Category: Sharpe, T]]
[[Category: Weigelt J]]
[[Category: Weigelt, J]]
[[Category: Apoptosis]]
[[Category: Apoptosis-hydrolase complex]]
[[Category: Atp-binding]]
[[Category: Developmental protein]]
[[Category: Differentiation]]
[[Category: Helicase]]
[[Category: Hydrolase]]
[[Category: Nucleotide-binding]]
[[Category: Nucleus]]
[[Category: Oogenesis]]
[[Category: Phosphoprotein]]
[[Category: Sgc]]
[[Category: Transcription regulation]]
[[Category: Ubl conjugation pathway]]

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