3ezz: Difference between revisions

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<StructureSection load='3ezz' size='340' side='right'caption='[[3ezz]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='3ezz' size='340' side='right'caption='[[3ezz]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3ezz]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EZZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EZZ FirstGlance]. <br>
<table><tr><td colspan='2'>[[3ezz]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EZZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EZZ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DUSP4, MKP2, VH2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ezz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ezz OCA], [https://pdbe.org/3ezz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ezz RCSB], [https://www.ebi.ac.uk/pdbsum/3ezz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ezz ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ezz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ezz OCA], [https://pdbe.org/3ezz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ezz RCSB], [https://www.ebi.ac.uk/pdbsum/3ezz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ezz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/DUS4_HUMAN DUS4_HUMAN]] Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.  
[https://www.uniprot.org/uniprot/DUS4_HUMAN DUS4_HUMAN] Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Jeong, D G]]
[[Category: Jeong DG]]
[[Category: Jung, S K]]
[[Category: Jung SK]]
[[Category: Kim, S J]]
[[Category: Kim SJ]]
[[Category: Ryu, S E]]
[[Category: Ryu SE]]
[[Category: Alpha/beta]]
[[Category: Hydrolase]]
[[Category: Nucleus]]
[[Category: Protein phosphatase]]

Latest revision as of 18:25, 1 November 2023

Crystal Structure of human MKP-2Crystal Structure of human MKP-2

Structural highlights

3ezz is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.9Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DUS4_HUMAN Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

3ezz, resolution 2.90Å

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