2znn: Difference between revisions
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<StructureSection load='2znn' size='340' side='right'caption='[[2znn]], [[Resolution|resolution]] 2.01Å' scene=''> | <StructureSection load='2znn' size='340' side='right'caption='[[2znn]], [[Resolution|resolution]] 2.01Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2znn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2znn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZNN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZNN FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=S44:(2S)-2-(4-PROPOXY-3-{[({4-[(3S,5S,7S)-TRICYCLO[3.3.1.1~3,7~]DEC-1-YL]PHENYL}CARBONYL)AMINO]METHYL}BENZYL)BUTANOIC+ACID'>S44</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=S44:(2S)-2-(4-PROPOXY-3-{[({4-[(3S,5S,7S)-TRICYCLO[3.3.1.1~3,7~]DEC-1-YL]PHENYL}CARBONYL)AMINO]METHYL}BENZYL)BUTANOIC+ACID'>S44</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2znn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2znn OCA], [https://pdbe.org/2znn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2znn RCSB], [https://www.ebi.ac.uk/pdbsum/2znn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2znn ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2znn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2znn OCA], [https://pdbe.org/2znn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2znn RCSB], [https://www.ebi.ac.uk/pdbsum/2znn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2znn ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/PPARA_HUMAN PPARA_HUMAN] Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2.<ref>PMID:7684926</ref> <ref>PMID:7629123</ref> <ref>PMID:9556573</ref> <ref>PMID:10195690</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Kasuga | [[Category: Kasuga J]] | ||
[[Category: Miyachi | [[Category: Miyachi H]] | ||
[[Category: Morikawa | [[Category: Morikawa K]] | ||
[[Category: Oyama | [[Category: Oyama T]] | ||
[[Category: Toyota | [[Category: Toyota K]] | ||