6lnh: Difference between revisions

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==Crystal structure of IDO from Bacillus thuringiensis==
==Crystal structure of IDO from Bacillus thuringiensis==
<StructureSection load='6lnh' size='340' side='right'caption='[[6lnh]]' scene=''>
<StructureSection load='6lnh' size='340' side='right'caption='[[6lnh]], [[Resolution|resolution]] 2.34&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LNH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6LNH FirstGlance]. <br>
<table><tr><td colspan='2'>[[6lnh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_thuringiensis Bacillus thuringiensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LNH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LNH FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6lnh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lnh OCA], [http://pdbe.org/6lnh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lnh RCSB], [http://www.ebi.ac.uk/pdbsum/6lnh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lnh ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.34&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lnh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lnh OCA], [https://pdbe.org/6lnh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lnh RCSB], [https://www.ebi.ac.uk/pdbsum/6lnh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lnh ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IDO_BACTU IDO_BACTU] Catalyzes the hydroxylation of L-isoleucine to produce (4S)-4-hydroxy-L-isoleucine (PubMed:20665018, PubMed:19850012, PubMed:21821743). Can also catalyze the hydroxylation of L-leucine, L-norvaline, L-norleucine and L-allo-isoleucine, as well as the sulfoxidation of L-methionine, L-ethionine, S-methyl-L-cysteine, S-ethyl-L-cysteine, and S-allyl-L-cysteine (PubMed:21821743).<ref>PMID:19850012</ref> <ref>PMID:20665018</ref> <ref>PMID:21821743</ref>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus thuringiensis]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Chen CC]]
[[Category: Chen CC]]

Latest revision as of 12:15, 25 October 2023

Crystal structure of IDO from Bacillus thuringiensisCrystal structure of IDO from Bacillus thuringiensis

Structural highlights

6lnh is a 4 chain structure with sequence from Bacillus thuringiensis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.34Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

IDO_BACTU Catalyzes the hydroxylation of L-isoleucine to produce (4S)-4-hydroxy-L-isoleucine (PubMed:20665018, PubMed:19850012, PubMed:21821743). Can also catalyze the hydroxylation of L-leucine, L-norvaline, L-norleucine and L-allo-isoleucine, as well as the sulfoxidation of L-methionine, L-ethionine, S-methyl-L-cysteine, S-ethyl-L-cysteine, and S-allyl-L-cysteine (PubMed:21821743).[1] [2] [3]

References

  1. ↑ Kodera T, Smirnov SV, Samsonova NN, Kozlov YI, Koyama R, Hibi M, Ogawa J, Yokozeki K, Shimizu S. A novel l-isoleucine hydroxylating enzyme, l-isoleucine dioxygenase from Bacillus thuringiensis, produces (2S,3R,4S)-4-hydroxyisoleucine. Biochem Biophys Res Commun. 2009 Dec 18;390(3):506-10. PMID:19850012 doi:10.1016/j.bbrc.2009.09.126
  2. ↑ Smirnov SV, Kodera T, Samsonova NN, Kotlyarova VA, Rushkevich NY, Kivero AD, Sokolov PM, Hibi M, Ogawa J, Shimizu S. Metabolic engineering of Escherichia coli to produce (2S, 3R, 4S)-4-hydroxyisoleucine. Appl Microbiol Biotechnol. 2010 Oct;88(3):719-26. PMID:20665018 doi:10.1007/s00253-010-2772-3
  3. ↑ Hibi M, Kawashima T, Kodera T, Smirnov SV, Sokolov PM, Sugiyama M, Shimizu S, Yokozeki K, Ogawa J. Characterization of Bacillus thuringiensis L-isoleucine dioxygenase for production of useful amino acids. Appl Environ Microbiol. 2011 Oct;77(19):6926-30. PMID:21821743 doi:10.1128/AEM.05035-11

6lnh, resolution 2.34Å

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