6f7u: Difference between revisions

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==Molecular Mechanism of ATP versus GTP Selectivity of Adenylate Kinase==
==Molecular Mechanism of ATP versus GTP Selectivity of Adenylate Kinase==
<StructureSection load='6f7u' size='340' side='right' caption='[[6f7u]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
<StructureSection load='6f7u' size='340' side='right'caption='[[6f7u]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6f7u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F7U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6F7U FirstGlance]. <br>
<table><tr><td colspan='2'>[[6f7u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F7U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6F7U FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">adk, EC55989_0487 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_kinase Adenylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.3 2.7.4.3] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6f7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f7u OCA], [https://pdbe.org/6f7u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6f7u RCSB], [https://www.ebi.ac.uk/pdbsum/6f7u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6f7u ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6f7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f7u OCA], [http://pdbe.org/6f7u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6f7u RCSB], [http://www.ebi.ac.uk/pdbsum/6f7u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6f7u ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/KAD_ECO55 KAD_ECO55]] Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.  
[https://www.uniprot.org/uniprot/KAD_ECOLI KAD_ECOLI] Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth.[HAMAP-Rule:MF_00235]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6f7u" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6f7u" style="background-color:#fffaf0;"></div>
==See Also==
*[[Adenylate kinase 3D structures|Adenylate kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Adenylate kinase]]
[[Category: Escherichia coli K-12]]
[[Category: Ecoli]]
[[Category: Large Structures]]
[[Category: Grundstrom, C]]
[[Category: Grundstrom C]]
[[Category: Hedberg, C]]
[[Category: Hedberg C]]
[[Category: Rogne, P]]
[[Category: Rogne P]]
[[Category: Rosselin, M]]
[[Category: Rosselin M]]
[[Category: Sauer, U H]]
[[Category: Sauer UH]]
[[Category: Wolf-Watz, M]]
[[Category: Wolf-Watz M]]
[[Category: Atp selectivity]]
[[Category: Gtp inhibition]]
[[Category: Inhibitor complex]]
[[Category: Transferase]]

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