2nsm: Difference between revisions
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<StructureSection load='2nsm' size='340' side='right'caption='[[2nsm]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='2nsm' size='340' side='right'caption='[[2nsm]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2nsm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2nsm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NSM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NSM FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nsm OCA], [https://pdbe.org/2nsm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nsm RCSB], [https://www.ebi.ac.uk/pdbsum/2nsm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nsm ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nsm OCA], [https://pdbe.org/2nsm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nsm RCSB], [https://www.ebi.ac.uk/pdbsum/2nsm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nsm ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
[https://www.uniprot.org/uniprot/CBPN_HUMAN CBPN_HUMAN] Defects in CPN1 are the cause of carboxypeptidase N deficiency (CPND) [MIM:[https://omim.org/entry/212070 212070]. Patients affected present some combination of angioedema or chronic urticaria, as well as hay fever or astma, and have also slightly depressed serum carboxy peptidase N, suggestive of autosomal recessive inheritance of this disorder.<ref>PMID:12560874</ref> | |||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/CBPN_HUMAN CBPN_HUMAN] Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation. | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Bode W]] | |||
[[Category: Bode | [[Category: Deddish PA]] | ||
[[Category: Deddish | [[Category: Erdoes EG]] | ||
[[Category: Erdoes | [[Category: Hoopes JT]] | ||
[[Category: Hoopes | [[Category: Huber R]] | ||
[[Category: Huber | [[Category: Keil C]] | ||
[[Category: Keil | [[Category: Maskos K]] | ||
[[Category: Maskos | [[Category: Skidgel RA]] | ||
[[Category: Skidgel | [[Category: Tan F]] | ||
[[Category: Tan | [[Category: Than M]] | ||
[[Category: Than | |||