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2nps: Difference between revisions

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<StructureSection load='2nps' size='340' side='right'caption='[[2nps]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='2nps' size='340' side='right'caption='[[2nps]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2nps]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat], [https://en.wikipedia.org/wiki/Human Human] and [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NPS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NPS FirstGlance]. <br>
<table><tr><td colspan='2'>[[2nps]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NPS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NPS FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Vamp4_predicted ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), syntaxin 13 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Vti1a ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), STX6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nps OCA], [https://pdbe.org/2nps PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nps RCSB], [https://www.ebi.ac.uk/pdbsum/2nps PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nps ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nps OCA], [https://pdbe.org/2nps PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nps RCSB], [https://www.ebi.ac.uk/pdbsum/2nps PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nps ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/STX6_HUMAN STX6_HUMAN]] Involved in intracellular vesicle trafficking. [[https://www.uniprot.org/uniprot/VAMP4_MOUSE VAMP4_MOUSE]] Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule (By similarity). [[https://www.uniprot.org/uniprot/VTI1A_RAT VTI1A_RAT]] V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2 (By similarity). May be concerned with increased secretion of cytokines associated with cellular senescence.<ref>PMID:17159904</ref>  [[https://www.uniprot.org/uniprot/STX12_RAT STX12_RAT]] SNARE that acts to regulate protein transport between endosomes and the trans-Golgi network (By similarity). The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro).<ref>PMID:17159904</ref> 
[https://www.uniprot.org/uniprot/VAMP4_MOUSE VAMP4_MOUSE] Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Buffalo rat]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Cypionka, A]]
[[Category: Rattus norvegicus]]
[[Category: Fasshauer, D]]
[[Category: Cypionka A]]
[[Category: Jahn, R]]
[[Category: Fasshauer D]]
[[Category: Pohl, W H]]
[[Category: Jahn R]]
[[Category: Wahl, M C]]
[[Category: Pohl WH]]
[[Category: Walla, P J]]
[[Category: Wahl MC]]
[[Category: Zwilling, D]]
[[Category: Walla PJ]]
[[Category: Early endosomal snare complex]]
[[Category: Zwilling D]]
[[Category: Snare complex]]
[[Category: Syntaxin 13]]
[[Category: Syntaxin 6]]
[[Category: Transport protein]]
[[Category: Vamp4]]
[[Category: Vesicle fusion]]
[[Category: Vti1a]]

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