2ddk: Difference between revisions

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<StructureSection load='2ddk' size='340' side='right'caption='[[2ddk]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='2ddk' size='340' side='right'caption='[[2ddk]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2ddk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DDK FirstGlance]. <br>
<table><tr><td colspan='2'>[[2ddk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DDK FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2czh|2czh]], [[2czi|2czi]], [[2czk|2czk]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IMPA2, IMP.18P ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Inositol-phosphate_phosphatase Inositol-phosphate phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.25 3.1.3.25] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ddk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ddk OCA], [https://pdbe.org/2ddk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ddk RCSB], [https://www.ebi.ac.uk/pdbsum/2ddk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ddk ProSAT], [https://www.topsan.org/Proteins/RSGI/2ddk TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ddk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ddk OCA], [https://pdbe.org/2ddk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ddk RCSB], [https://www.ebi.ac.uk/pdbsum/2ddk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ddk ProSAT], [https://www.topsan.org/Proteins/RSGI/2ddk TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/IMPA2_HUMAN IMPA2_HUMAN]] Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain.<ref>PMID:17068342</ref>
[https://www.uniprot.org/uniprot/IMPA2_HUMAN IMPA2_HUMAN] Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain.<ref>PMID:17068342</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Inositol-phosphate phosphatase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Arai, R]]
[[Category: Arai R]]
[[Category: Bessho, Y]]
[[Category: Bessho Y]]
[[Category: Ito, K]]
[[Category: Ito K]]
[[Category: Kamo-Uchikubo, T]]
[[Category: Kamo-Uchikubo T]]
[[Category: Ohba, H]]
[[Category: Ohba H]]
[[Category: Ohnishi, T]]
[[Category: Ohnishi T]]
[[Category: Structural genomic]]
[[Category: Shirouzu M]]
[[Category: Shirouzu, M]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S]]
[[Category: Yoshikawa T]]
[[Category: Yoshikawa, T]]
[[Category: Bipolar disorder]]
[[Category: Febrile seizure]]
[[Category: Hydrolase]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Rsgi]]
[[Category: Schizophrenia]]

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