1npu: Difference between revisions

Revision as of 02:50, 3 May 2008

CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF MURINE PD-1

OverviewOverview

PD-1, a member of the CD28/CTLA-4/ICOS costimulatory receptor family, delivers negative signals that have profound effects on T and B cell immunity. The 2.0 A crystal structure of the extracellular domain of murine PD-1 reveals an Ig V-type topology with overall similarity to the CTLA-4 monomer; however, there are notable differences in regions relevant to function. Our structural and biophysical data show that PD-1 is monomeric both in solution as well as on cell surface, in contrast to CTLA-4 and other family members that are all disulfide-linked homodimers. Furthermore, our structure-based mutagenesis studies identify the ligand binding surface of PD-1, which displays significant differences compared to those present in the other members of the family.

About this StructureAbout this Structure

1NPU is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

Structural and functional analysis of the costimulatory receptor programmed death-1., Zhang X, Schwartz JC, Guo X, Bhatia S, Cao E, Lorenz M, Cammer M, Chen L, Zhang ZY, Edidin MA, Nathenson SG, Almo SC, Immunity. 2004 Mar;20(3):337-47. PMID:15030777 Page seeded by OCA on Sat May 3 02:50:06 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:1npu.gif|left|200px]]
- {{Structure
+<!--
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+The line below this paragraph, containing "STRUCTURE_1npu", creates the "Structure Box" on the page.
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+You may change the PDB parameter (which sets the PDB file loaded into the applet)
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-|GENE= PDCD1 OR PD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
+-->
-|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=smart00409 IG]</span>
+{{STRUCTURE_1npu|  PDB=1npu  |  SCENE=  }}
-|RELATEDENTRY=[[1b88|1B88]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1npu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1npu OCA], [http://www.ebi.ac.uk/pdbsum/1npu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1npu RCSB]</span>
-}}
 '''CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF MURINE PD-1'''
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 [[Category: Zhang, X.]]
 [[Category: Zhang, Z Y.]]
-[[Category: ig v-type domain]]
+[[Category: Ig v-type domain]]
-[[Category: new york structural genomix research consortium]]
+[[Category: New york structural genomix research consortium]]
-[[Category: nysgxrc]]
+[[Category: Nysgxrc]]
-[[Category: protein structure initiative]]
+[[Category: Protein structure initiative]]
-[[Category: psi]]
+[[Category: Psi]]
-[[Category: structural genomic]]
+[[Category: Structural genomic]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 02:50:06 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:33:48 2008''