1q3p: Difference between revisions

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<StructureSection load='1q3p' size='340' side='right'caption='[[1q3p]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
<StructureSection load='1q3p' size='340' side='right'caption='[[1q3p]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1q3p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q3P OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1Q3P FirstGlance]. <br>
<table><tr><td colspan='2'>[[1q3p]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q3P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q3P FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1q3o|1q3o]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">shank1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q3p OCA], [https://pdbe.org/1q3p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q3p RCSB], [https://www.ebi.ac.uk/pdbsum/1q3p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q3p ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1q3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q3p OCA], [http://pdbe.org/1q3p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1q3p RCSB], [http://www.ebi.ac.uk/pdbsum/1q3p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1q3p ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SHAN1_RAT SHAN1_RAT]] Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Overexpression promotes maturation of dendritic spines and the enlargement of spine heads via its ability to recruit Homer to postsynaptic sites, and enhances presynaptic function.<ref>PMID:11498055</ref> <ref>PMID:18287537</ref>
[https://www.uniprot.org/uniprot/SHAN1_RAT SHAN1_RAT] Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Overexpression promotes maturation of dendritic spines and the enlargement of spine heads via its ability to recruit Homer to postsynaptic sites, and enhances presynaptic function.<ref>PMID:11498055</ref> <ref>PMID:18287537</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Buffalo rat]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Eom, S H]]
[[Category: Rattus norvegicus]]
[[Category: Im, Y J]]
[[Category: Eom SH]]
[[Category: Kang, G B]]
[[Category: Im YJ]]
[[Category: Kim, E]]
[[Category: Kang GB]]
[[Category: Lee, J H]]
[[Category: Kim E]]
[[Category: Park, S H]]
[[Category: Lee JH]]
[[Category: Park, S J]]
[[Category: Park SH]]
[[Category: Rho, S H]]
[[Category: Park SJ]]
[[Category: Gkap]]
[[Category: Rho S-H]]
[[Category: Pdz]]
[[Category: Peptide binding protein]]
[[Category: Shank]]

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