8sfe: Difference between revisions

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'''Unreleased structure'''


The entry 8sfe is ON HOLD  until Paper Publication
==Open state CCT-G beta 5 complex==
 
<StructureSection load='8sfe' size='340' side='right'caption='[[8sfe]], [[Resolution|resolution]] 3.36&Aring;' scene=''>
Authors: Wang, S., Sass, M., Willardson, B.M., Shen, P.S.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8sfe]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SFE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SFE FirstGlance]. <br>
Description: Open state CCT-G beta 5 complex
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.36&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
[[Category: Wang, S]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8sfe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8sfe OCA], [https://pdbe.org/8sfe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8sfe RCSB], [https://www.ebi.ac.uk/pdbsum/8sfe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8sfe ProSAT]</span></td></tr>
[[Category: Sass, M]]
</table>
[[Category: Shen, P.S]]
== Function ==
[[Category: Willardson, B.M]]
[https://www.uniprot.org/uniprot/TCPZ_HUMAN TCPZ_HUMAN] Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). The TRiC complex plays a role in the folding of actin and tubulin (Probable).<ref>PMID:25467444</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Sass M]]
[[Category: Shen PS]]
[[Category: Wang S]]
[[Category: Willardson BM]]

Revision as of 10:08, 25 October 2023

Open state CCT-G beta 5 complexOpen state CCT-G beta 5 complex

Structural highlights

8sfe is a 16 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Electron Microscopy, Resolution 3.36Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TCPZ_HUMAN Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). The TRiC complex plays a role in the folding of actin and tubulin (Probable).[1]

References

  1. ↑ Freund A, Zhong FL, Venteicher AS, Meng Z, Veenstra TD, Frydman J, Artandi SE. Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1. Cell. 2014 Dec 4;159(6):1389-403. doi: 10.1016/j.cell.2014.10.059. Epub 2014 Nov , 20. PMID:25467444 doi:http://dx.doi.org/10.1016/j.cell.2014.10.059

8sfe, resolution 3.36Å

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OCA
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