8ei2: Difference between revisions

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-'''Unreleased structure'''
-The entry 8ei2 is ON HOLD  until Paper Publication
+==Crystal structure of the N-terminal domain of CUL5 in complex with H314, a Helicon Polypeptide==
+<StructureSection load='8ei2' size='340' side='right'caption='[[8ei2]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-Authors: Li, K., Tokareva, O.S., Thomson, T.M., Verdine, G.L., McGee, J.H.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8ei2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EI2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EI2 FirstGlance]. <br>
-Description: Crystal structure of the N-terminal domain of CUL5 in complex with H314, a Helicon Polypeptide
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=WHL:N,N-(1,4-phenylene)diacetamide'>WHL</scene></td></tr>
-[[Category: Tokareva, O.S]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ei2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ei2 OCA], [https://pdbe.org/8ei2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ei2 RCSB], [https://www.ebi.ac.uk/pdbsum/8ei2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ei2 ProSAT]</span></td></tr>
-[[Category: Li, K]]
+</table>
-[[Category: Mcgee, J.H]]
+== Function ==
-[[Category: Verdine, G.L]]
+[https://www.uniprot.org/uniprot/CUL5_HUMAN CUL5_HUMAN] Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAk2. Seems to be involved poteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.
-[[Category: Thomson, T.M]]
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Synthetic construct]]
+[[Category: Li K]]
+[[Category: McGee JH]]
+[[Category: Thomson TM]]
+[[Category: Tokareva OS]]
+[[Category: Verdine GL]]