5lpn: Difference between revisions

<table><tr><td colspan='2'>[[5lpn]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LPN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LPN FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lpn OCA], [https://pdbe.org/5lpn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lpn RCSB], [https://www.ebi.ac.uk/pdbsum/5lpn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lpn ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/RAB10_HUMAN RAB10_HUMAN] The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane. In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response. Plays also a specific role in asymmetric protein transport to the plasma membrane within the polarized neuron and epithelial cells. In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane while in epithelial cells, it regulates transport from the Golgi to the basolateral membrane. Moreover, may play a role in the basolateral recycling pathway and in phagosome maturation. According to PubMed:23263280, may play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion.<ref>PMID:16641372</ref> <ref>PMID:21248164</ref> <ref>PMID:23263280</ref>  

[[Category: Homo sapiens]]

[[Category: Campos J]]

[[Category: Friese T]]

[[Category: Fu Y]]

[[Category: Gazdag EM]]

[[Category: Goody RS]]

[[Category: Itzen A]]

[[Category: Mueller MP]]

[[Category: Oprisko A]]

[[Category: Rai A]]