7uli: Difference between revisions
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==Apo HMG-CoA Reductase from Arabidopsis thaliana (HMG1)== | ==Apo HMG-CoA Reductase from Arabidopsis thaliana (HMG1)== | ||
<StructureSection load='7uli' size='340' side='right'caption='[[7uli]]' scene=''> | <StructureSection load='7uli' size='340' side='right'caption='[[7uli]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ULI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ULI FirstGlance]. <br> | <table><tr><td colspan='2'>[[7uli]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ULI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ULI FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uli FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uli OCA], [https://pdbe.org/7uli PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uli RCSB], [https://www.ebi.ac.uk/pdbsum/7uli PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uli ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uli FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uli OCA], [https://pdbe.org/7uli PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uli RCSB], [https://www.ebi.ac.uk/pdbsum/7uli PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uli ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/HMDH1_ARATH HMDH1_ARATH] Catalyzes the synthesis of mevalonate, the specific precursor of all isoprenoid compounds present in plants.<ref>PMID:14871314</ref> <ref>PMID:17917299</ref> <ref>PMID:19041104</ref> <ref>PMID:19363204</ref> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Decades of intense herbicide use has led to resistance in weeds. Without innovative weed management practices and new herbicidal modes of action, the unabated rise of herbicide resistance will undoubtedly place further stress upon food security. HMGR (3-hydroxy-3-methylglutaryl-coenzyme A reductase) is the rate limiting enzyme of the eukaryotic mevalonate pathway successfully targeted by statins to treat hypercholesterolemia in humans. As HMGR inhibitors have been shown to be herbicidal, HMGR could represent a mode of action target for the development of herbicides. Here, we present the crystal structure of a HMGR from Arabidopsis thaliana (AtHMG1) which exhibits a wider active site than previously determined structures from different species. This plant conserved feature enables the rational design of specific HMGR inhibitors and we develop a tolerance trait through sequence analysis of fungal gene clusters. These results suggest HMGR to be a viable herbicide target modifiable to provide a tolerance trait. | |||
A fungal tolerance trait and selective inhibitors proffer HMG-CoA reductase as a herbicide mode-of-action.,Haywood J, Breese KJ, Zhang J, Waters MT, Bond CS, Stubbs KA, Mylne JS Nat Commun. 2022 Sep 22;13(1):5563. doi: 10.1038/s41467-022-33185-0. PMID:36137996<ref>PMID:36137996</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 7uli" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[HMG-CoA Reductase 3D structures|HMG-CoA Reductase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Arabidopsis thaliana]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Bond CS]] | [[Category: Bond CS]] | ||
[[Category: Haywood J]] | [[Category: Haywood J]] | ||