7tfp: Difference between revisions

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<StructureSection load='7tfp' size='340' side='right'caption='[[7tfp]], [[Resolution|resolution]] 2.71&Aring;' scene=''>
<StructureSection load='7tfp' size='340' side='right'caption='[[7tfp]], [[Resolution|resolution]] 2.71&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7tfp]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TFP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TFP FirstGlance]. <br>
<table><tr><td colspan='2'>[[7tfp]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TFP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TFP FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I2V:(1S,3S,4S)-3-amino-4-(fluoromethyl)cyclopentane-1-carboxylic+acid'>I2V</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.71&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ornithine_aminotransferase Ornithine aminotransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.13 2.6.1.13] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I2V:(1S,3S,4S)-3-amino-4-(fluoromethyl)cyclopentane-1-carboxylic+acid'>I2V</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tfp OCA], [https://pdbe.org/7tfp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tfp RCSB], [https://www.ebi.ac.uk/pdbsum/7tfp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tfp ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tfp OCA], [https://pdbe.org/7tfp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tfp RCSB], [https://www.ebi.ac.uk/pdbsum/7tfp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tfp ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[https://www.uniprot.org/uniprot/OAT_HUMAN OAT_HUMAN]] Defects in OAT are the cause of hyperornithinemia with gyrate atrophy of choroid and retina (HOGA) [MIM:[https://omim.org/entry/258870 258870]]. HOGA is a slowly progressive blinding autosomal recessive disorder.<ref>PMID:3375240</ref> <ref>PMID:2793865</ref> <ref>PMID:1612597</ref> <ref>PMID:1737786</ref> <ref>PMID:7887415</ref> <ref>PMID:7668253</ref>
[https://www.uniprot.org/uniprot/OAT_HUMAN OAT_HUMAN] Defects in OAT are the cause of hyperornithinemia with gyrate atrophy of choroid and retina (HOGA) [MIM:[https://omim.org/entry/258870 258870]. HOGA is a slowly progressive blinding autosomal recessive disorder.<ref>PMID:3375240</ref> <ref>PMID:2793865</ref> <ref>PMID:1612597</ref> <ref>PMID:1737786</ref> <ref>PMID:7887415</ref> <ref>PMID:7668253</ref>  
== Function ==
[https://www.uniprot.org/uniprot/OAT_HUMAN OAT_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 7tfp" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7tfp" style="background-color:#fffaf0;"></div>
==See Also==
*[[Aminotransferase 3D structures|Aminotransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Ornithine aminotransferase]]
[[Category: Butrin A]]
[[Category: Butrin, A]]
[[Category: Liu D]]
[[Category: Liu, D]]
[[Category: Silverman R]]
[[Category: Silverman, R]]
[[Category: Zhu W]]
[[Category: Zhu, W]]
[[Category: Hoat]]
[[Category: Human ornithine aminotransferase]]
[[Category: Inactivator]]
[[Category: Irreversible inhibitor]]
[[Category: Mbi]]
[[Category: Mechanism-based inhibitor]]
[[Category: Oat]]
[[Category: Transferase]]

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