7sky: Difference between revisions
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<StructureSection load='7sky' size='340' side='right'caption='[[7sky]], [[Resolution|resolution]] 1.37Å' scene=''> | <StructureSection load='7sky' size='340' side='right'caption='[[7sky]], [[Resolution|resolution]] 1.37Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[7sky]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SKY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SKY FirstGlance]. <br> | <table><tr><td colspan='2'>[[7sky]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bordetella_pertussis Bordetella pertussis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SKY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SKY FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3700013Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sky OCA], [https://pdbe.org/7sky PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sky RCSB], [https://www.ebi.ac.uk/pdbsum/7sky PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sky ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sky OCA], [https://pdbe.org/7sky PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sky RCSB], [https://www.ebi.ac.uk/pdbsum/7sky PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sky ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/TOX1_BORPE TOX1_BORPE] S1 is an NAD-dependent ADP-ribosyltransferase, which plays a crucial role in the pathogenesis of B.pertussis causing disruption of normal host cellular regulation. It catalyzes the ADP-ribosylation of a cysteine in the alpha subunit of host heterotrimeric G proteins. In the absence of G proteins it also catalyzes the cleavage of NAD(+) into ADP-ribose and nicotinamide. It irreversibly uncouples the G-alpha GTP-binding proteins from their membrane receptors. | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 7sky" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 7sky" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Pertussis toxin|Pertussis toxin]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Bordetella pertussis]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Beddoe | [[Category: Beddoe T]] | ||
[[Category: Littler | [[Category: Littler DR]] | ||
[[Category: Pulliainen | [[Category: Pulliainen A]] | ||
[[Category: Rossjohn | [[Category: Rossjohn J]] | ||