7rou: Difference between revisions
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<StructureSection load='7rou' size='340' side='right'caption='[[7rou]], [[Resolution|resolution]] 1.70Å' scene=''> | <StructureSection load='7rou' size='340' side='right'caption='[[7rou]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[7rou]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ROU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ROU FirstGlance]. <br> | <table><tr><td colspan='2'>[[7rou]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ROU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ROU FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=66I:{(2R,3S,4R,5R)-5-[4-amino-3-(difluoromethoxy)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxyoxolan-2-yl}methyl+[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]sulfamate+(non-preferred+name)'>66I</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=66I:{(2R,3S,4R,5R)-5-[4-amino-3-(difluoromethoxy)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxyoxolan-2-yl}methyl+[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]sulfamate+(non-preferred+name)'>66I</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rou OCA], [https://pdbe.org/7rou PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rou RCSB], [https://www.ebi.ac.uk/pdbsum/7rou PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rou ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rou OCA], [https://pdbe.org/7rou PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rou RCSB], [https://www.ebi.ac.uk/pdbsum/7rou PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rou ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
[https://www.uniprot.org/uniprot/SYYC_HUMAN SYYC_HUMAN] Defects in YARS are the cause of Charcot-Marie-Tooth disease dominant intermediate type C (CMTDIC) [MIM:[https://omim.org/entry/608323 608323]. CMTDIC is a form of Charcot-Marie-Tooth disease characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec.<ref>PMID:16429158</ref> | |||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/SYYC_HUMAN SYYC_HUMAN] Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity). | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 7rou" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 7rou" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Griffin MDW]] | |||
[[Category: Griffin | [[Category: Metcalfe RD]] | ||
[[Category: Metcalfe | [[Category: Morton CJ]] | ||
[[Category: Morton | [[Category: Tilley L]] | ||
[[Category: Tilley | [[Category: Xie SC]] | ||
[[Category: Xie | |||