7rg1: Difference between revisions
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==== | ==Importin alpha2 in complex with MERS ORF4B H26A mutant== | ||
<StructureSection load='7rg1' size='340' side='right'caption='[[7rg1]]' scene=''> | <StructureSection load='7rg1' size='340' side='right'caption='[[7rg1]], [[Resolution|resolution]] 1.85Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[7rg1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Middle_East_respiratory_syndrome-related_coronavirus Middle East respiratory syndrome-related coronavirus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RG1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RG1 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rg1 OCA], [https://pdbe.org/7rg1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rg1 RCSB], [https://www.ebi.ac.uk/pdbsum/7rg1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rg1 ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rg1 OCA], [https://pdbe.org/7rg1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rg1 RCSB], [https://www.ebi.ac.uk/pdbsum/7rg1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rg1 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/IMA1_MOUSE IMA1_MOUSE] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. | |||
==See Also== | |||
*[[Importin 3D structures|Importin 3D structures]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Middle East respiratory syndrome-related coronavirus]] | ||
[[Category: Mus musculus]] | |||
[[Category: Aragao D]] | |||
[[Category: Forwood JK]] | |||
[[Category: Munasinghe TS]] | |||
[[Category: Roby JA]] | |||
[[Category: Tsimbalyuk S]] | |||