1nl3: Difference between revisions

Revision as of 02:39, 3 May 2008

CRYSTAL STRUCTURE OF THE SECA PROTEIN TRANSLOCATION ATPASE FROM MYCOBACTERIUM TUBERCULOSIS in APO FORM

OverviewOverview

In bacteria, the majority of exported proteins are translocated by the Sec system, which recognizes the signal sequence of a preprotein and uses ATP and the proton motive force to mediate protein translocation across the cytoplasmic membrane. SecA is an essential protein component of this system, containing the molecular motor that facilitates translocation. Here we report the three-dimensional structure of the SecA protein of Mycobacterium tuberculosis. Each subunit of the homodimer contains a "motor" domain and a translocation domain. The structure predicts that SecA can interact with the SecYEG pore and function as a molecular ratchet that uses ATP hydrolysis for physical movement of the preprotein. Knowledge of this structure provides a framework for further elucidation of the translocation process.

About this StructureAbout this Structure

1NL3 is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of Mycobacterium tuberculosis SecA, a preprotein translocating ATPase., Sharma V, Arockiasamy A, Ronning DR, Savva CG, Holzenburg A, Braunstein M, Jacobs WR Jr, Sacchettini JC, Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2243-8. Epub 2003 Feb 26. PMID:12606717 Page seeded by OCA on Sat May 3 02:39:45 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:1nl3.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1nl3 |SIZE=350|CAPTION= <scene name='initialview01'>1nl3</scene>, resolution 2.800&Aring;
+The line below this paragraph, containing "STRUCTURE_1nl3", creates the "Structure Box" on the page.
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-|LIGAND=
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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+or leave the SCENE parameter empty for the default display.
-|GENE= SECA1 OR SECA OR RV3240C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])
+-->
-|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam07516 SecA_SW], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam01043 SecA_PP_bind], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=smart00487 DEXDc], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK12904 PRK12904]</span>
+{{STRUCTURE_1nl3|  PDB=1nl3  |  SCENE=  }}
-|RELATEDENTRY=[[1nkt|1NKT]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nl3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nl3 OCA], [http://www.ebi.ac.uk/pdbsum/1nl3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1nl3 RCSB]</span>
-}}
 '''CRYSTAL STRUCTURE OF THE SECA PROTEIN TRANSLOCATION ATPASE FROM MYCOBACTERIUM TUBERCULOSIS in APO FORM'''
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 [[Category: Sharma, V.]]
 [[Category: TBSGC, TB Structural Genomics Consortium.]]
-[[Category: atpase]]
+[[Category: Atpase]]
-[[Category: helicase-like motor domain]]
+[[Category: Helicase-like motor domain]]
-[[Category: preprotein translocation]]
+[[Category: Preprotein translocation]]
-[[Category: protein structure initiative]]
+[[Category: Protein structure initiative]]
-[[Category: psi]]
+[[Category: Psi]]
-[[Category: structural genomic]]
+[[Category: Structural genomic]]
-[[Category: tb structural genomics consortium]]
+[[Category: Tb structural genomics consortium]]
-[[Category: tbsgc]]
+[[Category: Tbsgc]]
-[[Category: transmembrane transport]]
+[[Category: Transmembrane transport]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 02:39:45 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:31:49 2008''