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==Human TDO (hTDO) in complex with NLG919 analog== | ==Human TDO (hTDO) in complex with NLG919 analog== | ||
<StructureSection load='7lu7' size='340' side='right'caption='[[7lu7]]' scene=''> | <StructureSection load='7lu7' size='340' side='right'caption='[[7lu7]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LU7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LU7 FirstGlance]. <br> | <table><tr><td colspan='2'>[[7lu7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LU7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LU7 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lu7 OCA], [https://pdbe.org/7lu7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lu7 RCSB], [https://www.ebi.ac.uk/pdbsum/7lu7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lu7 ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5PK:(1~{R})-1-CYCLOHEXYL-2-[(5~{S})-5~{H}-IMIDAZO[1,5-B]ISOINDOL-5-YL]ETHANOL'>5PK</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=ZIQ:alpha-methyl-L-tryptophan'>ZIQ</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lu7 OCA], [https://pdbe.org/7lu7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lu7 RCSB], [https://www.ebi.ac.uk/pdbsum/7lu7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lu7 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/T23O_HUMAN T23O_HUMAN] Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin (By similarity). | |||
==See Also== | |||
*[[Dioxygenase 3D structures|Dioxygenase 3D structures]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Yeh S-R]] | [[Category: Yeh S-R]] | ||
Revision as of 18:59, 18 October 2023
Human TDO (hTDO) in complex with NLG919 analogHuman TDO (hTDO) in complex with NLG919 analog
Structural highlights
FunctionT23O_HUMAN Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin (By similarity). See Also |
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