7l8q: Difference between revisions
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==Crystal structure of human GPX4-U46C with oxidized Cys-46== | ==Crystal structure of human GPX4-U46C with oxidized Cys-46== | ||
<StructureSection load='7l8q' size='340' side='right'caption='[[7l8q]]' scene=''> | <StructureSection load='7l8q' size='340' side='right'caption='[[7l8q]], [[Resolution|resolution]] 1.48Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7L8Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7L8Q FirstGlance]. <br> | <table><tr><td colspan='2'>[[7l8q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7L8Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7L8Q FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7l8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7l8q OCA], [https://pdbe.org/7l8q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7l8q RCSB], [https://www.ebi.ac.uk/pdbsum/7l8q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7l8q ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.48Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7l8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7l8q OCA], [https://pdbe.org/7l8q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7l8q RCSB], [https://www.ebi.ac.uk/pdbsum/7l8q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7l8q ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/GPX4_HUMAN GPX4_HUMAN] Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity). | |||
==See Also== | |||
*[[Glutathione peroxidase|Glutathione peroxidase]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Conrad M]] | [[Category: Conrad M]] | ||