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==== | ==Crystal structure of BbKI complexed with Human Kallikrein 4== | ||
<StructureSection load='7joe' size='340' side='right'caption='[[7joe]]' scene=''> | <StructureSection load='7joe' size='340' side='right'caption='[[7joe]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[7joe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bauhinia_bauhinioides Bauhinia bauhinioides] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JOE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JOE FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7joe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7joe OCA], [https://pdbe.org/7joe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7joe RCSB], [https://www.ebi.ac.uk/pdbsum/7joe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7joe ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7joe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7joe OCA], [https://pdbe.org/7joe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7joe RCSB], [https://www.ebi.ac.uk/pdbsum/7joe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7joe ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | |||
[https://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN] Defects in KLK4 are the cause of amelogenesis imperfecta hypomaturation type 2A1 (AI2A1) [MIM:[https://omim.org/entry/204700 204700]. AI2A1 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.<ref>PMID:15235027</ref> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN] Involved in enamel formation.<ref>PMID:15235027</ref> | |||
==See Also== | |||
*[[Kallikrein 3D structures|Kallikrein 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Bauhinia bauhinioides]] | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Gustchina A]] | ||
[[Category: Li M]] | |||
[[Category: Wlodawer A]] | |||
Latest revision as of 18:08, 18 October 2023
Crystal structure of BbKI complexed with Human Kallikrein 4Crystal structure of BbKI complexed with Human Kallikrein 4
Structural highlights
DiseaseKLK4_HUMAN Defects in KLK4 are the cause of amelogenesis imperfecta hypomaturation type 2A1 (AI2A1) [MIM:204700. AI2A1 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.[1] FunctionKLK4_HUMAN Involved in enamel formation.[2] See AlsoReferences
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