6v8f: Difference between revisions

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 ==Crystal structure of recombinat mutant Q185R of human fumarase==
-<StructureSection load='6v8f' size='340' side='right'caption='[[6v8f]]' scene=''>
+<StructureSection load='6v8f' size='340' side='right'caption='[[6v8f]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V8F OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6V8F FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6v8f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V8F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6V8F FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6v8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v8f OCA], [http://pdbe.org/6v8f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6v8f RCSB], [http://www.ebi.ac.uk/pdbsum/6v8f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6v8f ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6v8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v8f OCA], [https://pdbe.org/6v8f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6v8f RCSB], [https://www.ebi.ac.uk/pdbsum/6v8f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6v8f ProSAT]</span></td></tr>
 </table>
+== Disease ==
+[https://www.uniprot.org/uniprot/FUMH_HUMAN FUMH_HUMAN] Defects in FH are the cause of fumarase deficiency (FHD) [MIM:[https://omim.org/entry/606812 606812]; also known as fumaricaciduria. FHD is characterized by progressive encephalopathy, developmental delay, hypotonia, cerebral atrophy and lactic and pyruvic acidemia.[:]<ref>PMID:9635293</ref>   Defects in FH are the cause of hereditary leiomyomatosis and renal cell cancer (HLRCC) [MIM:[https://omim.org/entry/150800 150800]. A disorder characterized by predisposition to cutaneous and uterine leiomyomas, and papillary type 2 renal cancer which occurs in about 20% of patients.<ref>PMID:11865300</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/FUMH_HUMAN FUMH_HUMAN] Also acts as a tumor suppressor.
+==See Also==
+*[[Fumarase|Fumarase]]
+== References ==
+<references/>
 __TOC__
 </StructureSection>
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
 [[Category: Ajalla MAA]]
 [[Category: Nonato MC]]