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==Crystal structure of human GAC in complex with inhibitor UPGL00012== | ==Crystal structure of human GAC in complex with inhibitor UPGL00012== | ||
<StructureSection load='6umf' size='340' side='right'caption='[[6umf]]' scene=''> | <StructureSection load='6umf' size='340' side='right'caption='[[6umf]], [[Resolution|resolution]] 2.68Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UMF OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[6umf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UMF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UMF FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.68Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QAM:N-(5-{[1-(5-amino-1,3,4-thiadiazol-2-yl)piperidin-4-yl]oxy}-1,3,4-thiadiazol-2-yl)-2-phenylacetamide'>QAM</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6umf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6umf OCA], [https://pdbe.org/6umf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6umf RCSB], [https://www.ebi.ac.uk/pdbsum/6umf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6umf ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/GLSK_HUMAN GLSK_HUMAN] Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity. | |||
==See Also== | |||
*[[Glutaminase 3D structures|Glutaminase 3D structures]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Cerione RA]] | [[Category: Cerione RA]] | ||
[[Category: Huang Q]] | [[Category: Huang Q]] | ||
Latest revision as of 10:54, 11 October 2023
Crystal structure of human GAC in complex with inhibitor UPGL00012Crystal structure of human GAC in complex with inhibitor UPGL00012
Structural highlights
FunctionGLSK_HUMAN Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity. See Also |
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