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==Structure of human ketohexokinase-C in complex with fructose, NO3, and osthole== | ==Structure of human ketohexokinase-C in complex with fructose, NO3, and osthole== | ||
<StructureSection load='6ul7' size='340' side='right'caption='[[6ul7]]' scene=''> | <StructureSection load='6ul7' size='340' side='right'caption='[[6ul7]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UL7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UL7 FirstGlance]. <br> | <table><tr><td colspan='2'>[[6ul7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UL7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UL7 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ul7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ul7 OCA], [https://pdbe.org/6ul7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ul7 RCSB], [https://www.ebi.ac.uk/pdbsum/6ul7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ul7 ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A0O:7-methoxy-8-(3-methylbut-2-enyl)chromen-2-one'>A0O</scene>, <scene name='pdbligand=FRU:FRUCTOSE'>FRU</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ul7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ul7 OCA], [https://pdbe.org/6ul7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ul7 RCSB], [https://www.ebi.ac.uk/pdbsum/6ul7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ul7 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | |||
[https://www.uniprot.org/uniprot/KHK_HUMAN KHK_HUMAN] Defects in KHK are the cause of fructosuria (FRUCT) [MIM:[https://omim.org/entry/229800 229800]. Benign defect of intermediary metabolism.<ref>PMID:19237742</ref> <ref>PMID:7833921</ref> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/KHK_HUMAN KHK_HUMAN] | |||
==See Also== | |||
*[[Ketohexokinase|Ketohexokinase]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Allen KN]] | [[Category: Allen KN]] | ||
Latest revision as of 10:53, 11 October 2023
Structure of human ketohexokinase-C in complex with fructose, NO3, and ostholeStructure of human ketohexokinase-C in complex with fructose, NO3, and osthole
Structural highlights
DiseaseKHK_HUMAN Defects in KHK are the cause of fructosuria (FRUCT) [MIM:229800. Benign defect of intermediary metabolism.[1] [2] FunctionSee AlsoReferences
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