6tzc: Difference between revisions

<table><tr><td colspan='2'>[[6tzc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Asfb7 Asfb7] and [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TZC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TZC FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAL:MALTOSE'>MAL</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">malE, b4034, JW3994 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI]), Ba71V-041, A179L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10498 ASFB7])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6tzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tzc OCA], [http://pdbe.org/6tzc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tzc RCSB], [http://www.ebi.ac.uk/pdbsum/6tzc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tzc ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides. [[http://www.uniprot.org/uniprot/BECN1_PIG BECN1_PIG]] Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis. May play a role in antiviral host defense (By similarity).[UniProtKB:O88597][UniProtKB:Q14457][UniProtKB:Q91XJ1]  Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.[UniProtKB:O88597][UniProtKB:Q14457] [[http://www.uniprot.org/uniprot/ARBH_ASFB7 ARBH_ASFB7]] Suppresses apoptosis in host cell and thus facilitates production of progeny virions (PubMed:9123849, PubMed:18329683). Has the ability to potentially bind to all the members of the proapoptotic Bcl-2 family (PubMed:28053104, PubMed:18329683).<ref>PMID:18329683</ref> <ref>PMID:28053104</ref> <ref>PMID:9123849</ref> 

[[Category: Asfb7]]

[[Category: Ecoli]]

[[Category: Banjara, S]]

[[Category: Hinds, M G]]

[[Category: Kvansakul, M]]

[[Category: Apoptosis]]

[[Category: Structural protein-apoptosis complex]]